Research Articles
Epigenetic Clocks in Clinical Research: A Guide to Biomarker Selection, Application, and Validation
This article provides a comprehensive overview of epigenetic clocks for researchers, scientists, and drug development professionals.
A Complete Workflow for Cell-Free DNA Methylation Biomarker Discovery: From Liquid Biopsy to Clinical Application
This article provides a comprehensive guide for researchers and drug development professionals on the end-to-end workflow for discovering and validating cell-free DNA (cfDNA) methylation biomarkers.
EWAS Design and Analysis: A Comprehensive Guide for Biomedical Researchers
This article provides a comprehensive guide to Epigenome-Wide Association Study (EWAS) design and analysis, tailored for researchers, scientists, and drug development professionals.
Bisulfite Sequencing: The Definitive Guide to Genome-Wide DNA Methylation Mapping for Researchers
This article provides a comprehensive resource for researchers and drug development professionals on bisulfite sequencing (BS-Seq), the gold-standard technique for mapping DNA methylation at single-base resolution.
A Comprehensive Guide to ChIP-seq for Histone Modification Analysis: From Foundational Principles to Advanced Applications
This article provides a comprehensive guide to Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) for mapping histone modifications, a critical technology in epigenomics.
Single-Cell ATAC-Seq: A Comprehensive Guide to Chromatin Accessibility Profiling in Biomedical Research
Single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) has emerged as a transformative technology for mapping the epigenetic landscape of individual cells within complex tissues.
CRISPR-dCas9 Epigenetic Editing: A Comprehensive Guide for Functional Validation in Biomedical Research
This article provides a detailed overview of CRISPR-dCas9-based epigenetic editing for the functional validation of genetic targets.
Decoding X-Chromosome Inactivation: Epigenetic Mechanisms, Methodologies, and Clinical Implications
This article provides a comprehensive analysis of the epigenetic regulation of X-chromosome inactivation (XCI), a fundamental process in mammalian dosage compensation.
Environmental Exposures and Transgenerational Epigenetic Inheritance: Mechanisms, Evidence, and Therapeutic Implications
This article synthesizes current research on how environmental factors—including toxicants, nutrition, and stress—induce epigenetic modifications that can be transmitted across generations, influencing disease susceptibility in unexposed descendants.
The Epigenetic Triad: Decoding the Interplay of Non-Coding RNAs, DNA Methylation, and Histone Modifications
This article provides a comprehensive analysis of the sophisticated crosstalk between non-coding RNAs (ncRNAs), DNA methylation, and histone modifications—the core pillars of epigenetic regulation.