Research Articles
Beyond Chronological Age: A Comprehensive Comparison of Second-Generation vs. First-Generation Epigenetic Clocks for Research and Drug Development
This article provides a systematic comparison of first- and second-generation epigenetic clocks for a scientific audience.
Locus-Specific vs. Genome-Wide DNA Methylation Analysis: A Strategic Guide for Biomedical Researchers
Selecting the appropriate DNA methylation analysis method is a critical strategic decision that directly impacts the success and cost-effectiveness of epigenetic research and biomarker development.
Assessing Reproducibility in 3D Genomics: A Comprehensive Guide to Chromatin Conformation Capture Techniques
This article provides a comprehensive framework for assessing the reproducibility of Chromatin Conformation Capture (3C) techniques, which are pivotal for understanding 3D genome organization in health and disease.
Validating the Clock: How Epigenetic Age Acceleration Predicts Mortality and Morbidity in Modern Cohorts
This article synthesizes current evidence validating epigenetic age acceleration (EAA) as a robust biomarker for mortality and morbidity risk.
Validating Epigenetic Biomarkers for Early Cancer Detection: From Discovery to Clinical Implementation
This article provides a comprehensive analysis of the validation pipeline for epigenetic biomarkers in early cancer detection, tailored for researchers and drug development professionals.
DNA Methylation Landscapes in Cancer Metastasis: From Primary Tumors to Disseminated Disease
This article synthesizes current research on DNA methylation patterns differentiating primary tumors from metastases, a critical area for understanding cancer progression.
Evaluating Machine Learning Tools for Epigenetic Data Analysis: A 2025 Guide for Researchers and Developers
This article provides a comprehensive evaluation of machine learning (ML) tools and methodologies for analyzing complex epigenetic data.
Definitive Guide to Histone Modification Antibody Validation for Reliable ChIP Data
This comprehensive guide addresses the critical challenge of validating histone modification antibodies for Chromatin Immunoprecipitation (ChIP) experiments.
Comparing Epigenetic Clocks for Disease Prediction: Accuracy, Clinical Applications, and Future Directions
This article provides a comprehensive comparison of epigenetic clocks, powerful DNA methylation-based biomarkers for biological age and disease risk.
Benchmarking DNA Methylation Analysis: A Comprehensive Guide to Sequencing vs. Array Technologies for Biomedical Research
This article provides a systematic comparison of DNA methylation analysis platforms, focusing on the critical choice between sequencing-based methods and methylation microarrays.