Research Articles
CRISPRa vs CRISPRi: Choosing the Right Strategy for Precision Transcriptional Control in Research and Therapeutics
This comprehensive guide for researchers and drug development professionals demystifies the competing CRISPR technologies for transcriptional modulation: CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi).
Unlocking X-Inactivation: A Guide to CRISPR Screening for Non-Coding RNA and Epigenetic Regulators
This comprehensive guide details the application of CRISPR/Cas9 screening to identify and validate key factors in X-chromosome inactivation (XCI), a vital epigenetic process.
Unraveling Genome Architecture: A CRISPR-Cas9 Guide to CTCF Site Inversion for Functional Genomics
This article provides a comprehensive guide for researchers on using CRISPR-Cas9-mediated inversion of CTCF binding sites to study their functional role in 3D genome organization and gene regulation.
CRISPR Epigenetic Editing: Mastering Bidirectional Regulatory Circuits for Precision Medicine
This article provides a comprehensive guide for researchers and drug developers on CRISPR-based bidirectional epigenetic regulatory circuits.
Beyond the Code: A Comprehensive Review of CRISPR as an Epigenetic Programming Tool
This review provides a detailed analysis of CRISPR technology's evolution into a powerful platform for targeted epigenetic engineering.
CHIPIN ChIP-seq Normalization: The Complete Guide for Accurate Inter-Sample Analysis in Biomedical Research
This comprehensive guide explores CHIPIN (ChIP-seq Inter-sample Normalization), a critical method for ensuring robust and comparable analysis across multiple ChIP-seq experiments.
CAP-C Crosslinking: The Ultimate Guide to Protein-Protein Interaction Mapping for Drug Discovery
This comprehensive guide explores CAP-C (Crosslink-Assisted Proximity Capture), a cutting-edge chemical crosslinking and mass spectrometry technique revolutionizing the study of protein-protein interactions (PPIs).
A Comprehensive Guide to Bioconductor for DNA Methylation Array Analysis: From QC to Clinical Insight
This article provides a complete roadmap for analyzing DNA methylation array data using Bioconductor, the premier open-source software project for bioinformatics in R.
Mastering Reproducibility: A Step-by-Step Guide to Reliable Hi-C Library Preparation
This comprehensive guide details best practices for achieving robust and reproducible Hi-C library preparation, essential for high-quality 3D genomics data.
Benchmarking HiChIP Analysis Tools: A Comprehensive Guide for Researchers and Drug Developers
This article provides a comprehensive benchmark and practical guide for analyzing HiChIP data, a key technique for mapping enhancer-promoter interactions in gene regulation.