Research Articles
Decoding the 3D Genome: A Comprehensive Guide to Hi-C and 3C-Based Technologies for Researchers
This article provides a comprehensive examination of Hi-C and 3C-based technologies for mapping the three-dimensional architecture of the genome.
Epigenetic Clocks in Clinical Research: A Guide to Biomarker Selection, Application, and Validation
This article provides a comprehensive overview of epigenetic clocks for researchers, scientists, and drug development professionals.
A Complete Workflow for Cell-Free DNA Methylation Biomarker Discovery: From Liquid Biopsy to Clinical Application
This article provides a comprehensive guide for researchers and drug development professionals on the end-to-end workflow for discovering and validating cell-free DNA (cfDNA) methylation biomarkers.
EWAS Design and Analysis: A Comprehensive Guide for Biomedical Researchers
This article provides a comprehensive guide to Epigenome-Wide Association Study (EWAS) design and analysis, tailored for researchers, scientists, and drug development professionals.
Bisulfite Sequencing: The Definitive Guide to Genome-Wide DNA Methylation Mapping for Researchers
This article provides a comprehensive resource for researchers and drug development professionals on bisulfite sequencing (BS-Seq), the gold-standard technique for mapping DNA methylation at single-base resolution.
A Comprehensive Guide to ChIP-seq for Histone Modification Analysis: From Foundational Principles to Advanced Applications
This article provides a comprehensive guide to Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) for mapping histone modifications, a critical technology in epigenomics.
Single-Cell ATAC-Seq: A Comprehensive Guide to Chromatin Accessibility Profiling in Biomedical Research
Single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) has emerged as a transformative technology for mapping the epigenetic landscape of individual cells within complex tissues.
CRISPR-dCas9 Epigenetic Editing: A Comprehensive Guide for Functional Validation in Biomedical Research
This article provides a detailed overview of CRISPR-dCas9-based epigenetic editing for the functional validation of genetic targets.
Decoding X-Chromosome Inactivation: Epigenetic Mechanisms, Methodologies, and Clinical Implications
This article provides a comprehensive analysis of the epigenetic regulation of X-chromosome inactivation (XCI), a fundamental process in mammalian dosage compensation.
Environmental Exposures and Transgenerational Epigenetic Inheritance: Mechanisms, Evidence, and Therapeutic Implications
This article synthesizes current research on how environmental factors—including toxicants, nutrition, and stress—induce epigenetic modifications that can be transmitted across generations, influencing disease susceptibility in unexposed descendants.