Research Articles
From Association to Function: Advanced Strategies for Validating EWAS Hits in Disease Research
Epigenome-Wide Association Studies (EWAS) have become a cornerstone for identifying epigenetic variants, primarily DNA methylation marks, associated with complex diseases.
Essential Best Practices for Robust Quality Control in DNA Methylation Microarray Data
This article provides a comprehensive guide to quality control (QC) for DNA methylation microarray data, a critical step for ensuring robust and replicable findings in epigenome-wide association studies (EWAS).
Enhancing Resolution and Accuracy in Single-Cell Epigenomics: A Guide to Advanced Protocols and Data Analysis
Single-cell epigenomics has revolutionized our understanding of cellular heterogeneity, yet challenges in protocol resolution and data accuracy persist.
Standardizing Epigenetic Clock Analysis: A Cross-Tissue Framework for Reliable Biomarker Application
Epigenetic clocks have emerged as powerful tools for estimating biological age, yet their application is hampered by significant variability in predictions across different tissues.
Mitigating Batch Effects in EWAS: A Comprehensive Guide from Study Design to Data Validation
This article provides a comprehensive guide for researchers and scientists on addressing the critical challenge of batch effects in large-scale Epigenome-Wide Association Studies (EWAS).
Strategies to Overcome the High Cost of Epigenetic Sequencing: A Guide for Researchers and Developers
This article addresses the significant challenge of high costs associated with epigenetic sequencing platforms, a primary barrier for researchers and drug development professionals.
Navigating the Labyrinth: A Practical Guide to Interpreting Complex Epigenomic Data
This guide provides researchers, scientists, and drug development professionals with a comprehensive framework for tackling the inherent complexities of epigenomic data interpretation.
Optimizing Bisulfite Conversion Efficiency: A Comprehensive Guide for Accurate DNA Methylation Sequencing
This article provides a definitive guide for researchers and drug development professionals on optimizing bisulfite conversion, the foundational step for DNA methylation sequencing.
Integrative Bioinformatics Pipelines for Multi-Omics Epigenetics Data: From Foundational Concepts to Clinical Translation
This article provides a comprehensive guide for researchers, scientists, and drug development professionals on integrative bioinformatics pipelines for multi-omics epigenetics data.
Optimized Protocol for Nuclei Isolation from Frozen Postmortem Brain Tissue: A Guide for Single-Cell Omics
This article provides a comprehensive guide for researchers and drug development professionals on isolating high-quality nuclei from frozen postmortem brain tissue, a critical step for single-nuclei RNA sequencing (snRNA-seq) and...